Beilstein J. Nanotechnol.2014,5, 313–322, doi:10.3762/bjnano.5.35
that combine imaging and therapeutic agents. In our study, we use a new biocompatible and biodegradable polymer, termed poly(glycerolmalateco-dodecanedioate) (PGMD), for the synthesis of nanoparticles (NPs) and loading of near-infrared (NIR) dyes. IR820 was chosen for the purpose of imaging and
of both transcription factors.
Keywords: hypoxia-inducible factor-1; IR820; nanoparticle; poly(glycerolmalateco-dodecanedioate) (PGMD); vascular endothelial growth factor; Introduction
The synthesis and development of novel polymers and their use for nanoparticle (NP) synthesis has been an
endothelial growth factor (VEGF), and poor lymphatic clearance from tumor sites [4]. Because of these advantages, we synthesized a new formulation of polymeric NPs for image-guided therapy based on the polymer poly(glycerolmalateco-dodecanedioate) (PGMD) developed in our lab. The work described in this
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Figure 1:
Subcellular localization of free IR820 (A) and IR820-PGMD NPs (B) in SKOV-3 after 24-hour incubatio...